Generally, the structure and function of blood vessels, particularly small vessels and their alterations during inflammation. More specifically, the inner glycocalyx, pericytes, endothelial cells and the connective tissues of blood vessels, which are affected by inflammation and other challenges.
Research Interests:
Generally, the structure and function of blood vessels, particularly small
vessels and their alterations during inflammation
Specifically, the inner glycocalyx, pericytes, endothelial cells and the
connective tissues of blood vessels, which are affected by inflammation and
other challenges
Citations:
Lentsch, A.B., M.J. Edwards, D.E. Sims and
F.N. Miller. N -nitro-L-arginine methyl ester inhibits inflammatory liver
injury induced by interleukin-2. Journal of Leukocyte Biology, 63:22-30,
1998.
Lopez, A., D.E. Sims, R.F. Ablett, R.E.
Skinner, L.W. Leger, C.M. Lariviere, L.A. Jamieson, J. Martinez-Burnes, and G.G.
Zawadzka. Effect of emu oil on auricular inflammation induced with croton oil in
mice. American Journal of Veterinary Research 60:1558-1561, 1999.
Sims, D.E. Diversity within pericytes.
Clinical and Experimental Pharmacology and Physiology, 27:842-846,
2000.
Fast, M.D., D.E. Sims, J.F. Burka, A. Mustafa,
and N.W. Ross. (2002). Skin morphology and humoral non-specific defense
parameters of mucus and plasma in rainbow trout, coho and Atlantic salmon.
Comparative Biochemistry and Physiology, Part A, 132, 645-657.
Kwan, J.A., C.J. Schulze, W. Wang, H. Leon. M.
Sariahmetoglu, M. Sung, J. Sawicka, D. Sims, G. Sawicki and R. Schulz. Matrix
metalloproteinase-2 (MMP-2) is present in the nucleus of cardiac myocytes and is
capable of cleaving poly (ADP-ribose) polymerase (PARP) in vitro. FASEB Journal
18(6):690-2, 2004.
Current Collaborators (non-UPEI):
Dr. Alison Fox-Robichaud, Faculty of Medicine, McMaster University
Dr. Richard Schulz, Faculty of Medicine, University of Alberta
Dr. Ann Baldwin, Faculty of Medicine, University of Arizona
