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David E. Sims

Generally, the structure and function of blood vessels, particularly small vessels and their alterations during inflammation. More specifically, the inner glycocalyx, pericytes, endothelial cells and the connective tissues of blood vessels, which are affected by inflammation and other challenges.

Degrees: 
  • B.A., University of Western Ontario, 1972
  • M. Eng., University of Western Ontario, 1974
  • Ph.D., Kansas Sate University, 1981
Position: 
Professor
Department: 
Biomedical Sciences
Faculty: 
Veterinary Medicine
Phone: 
(902) 566-0812
Research Interests: 
  • Generally, the structure and function of blood vessels, particularly small vessels and their alterations during inflammation
  • Specifically, the inner glycocalyx, pericytes, endothelial cells and the connective tissues of blood vessels, which are affected by inflammation and other challenges
Citations: 
  1. Lentsch, A.B., M.J. Edwards, D.E. Sims and F.N. Miller. N -nitro-L-arginine methyl ester inhibits inflammatory liver injury induced by interleukin-2. Journal of Leukocyte Biology, 63:22-30, 1998.
  2. Lopez, A., D.E. Sims, R.F. Ablett, R.E. Skinner, L.W. Leger, C.M. Lariviere, L.A. Jamieson, J. Martinez-Burnes, and G.G. Zawadzka. Effect of emu oil on auricular inflammation induced with croton oil in mice. American Journal of Veterinary Research 60:1558-1561, 1999.
  3. Sims, D.E. Diversity within pericytes. Clinical and Experimental Pharmacology and Physiology, 27:842-846, 2000.
  4. Fast, M.D., D.E. Sims, J.F. Burka, A. Mustafa, and N.W. Ross. (2002). Skin morphology and humoral non-specific defense parameters of mucus and plasma in rainbow trout, coho and Atlantic salmon. Comparative Biochemistry and Physiology, Part A, 132, 645-657.
  5. Kwan, J.A., C.J. Schulze, W. Wang, H. Leon. M. Sariahmetoglu, M. Sung, J. Sawicka, D. Sims, G. Sawicki and R. Schulz. Matrix metalloproteinase-2 (MMP-2) is present in the nucleus of cardiac myocytes and is capable of cleaving poly (ADP-ribose) polymerase (PARP) in vitro. FASEB Journal 18(6):690-2, 2004.
Current Collaborators (non-UPEI): 
  • Dr. Alison Fox-Robichaud, Faculty of Medicine, McMaster University
  • Dr. Richard Schulz, Faculty of Medicine, University of Alberta
  • Dr. Ann Baldwin, Faculty of Medicine, University of Arizona