The Marine Natural Products Group at the University of Prince Edward Island is engaged in projects directed at the development of sustainable production methods of bioactive marine metabolites and discovering new bioactive bioproducts. The latter group includes natural products with activities in assays of relevance to human and animal health, and with activity as antifouling agents.
natural products isolation and characterization
bioassay-guided purification of natural products / drug discovery
isolation of natural product producing bacteria and fungi
development of fermentation methods to optimize natural product production
description of microbial communities in marine invertebrates
Jose Lopez, Benoit Mouzon, Peter McCarthy, Russell Kerr. The many faces of gene expression profiling: transcriptome analyses applied towards elucidating marine organismal interactions and metabolism. Chapter in "Recent Advancements in Biotechnology", in press (2009).
Abhijeet Kate, Jason Pearson, Balaji Ramanathan, Kelly Richard, Russell Kerr. Isolation, biomimetic synthesis and biological activity of bis-pseudopterane amines. J. Nat. Prod. in press (2009).
Jose Lopez, Lanie Ranzer, A. Ledger, Schoch, Alan Duckworth, Peter McCarthy and Russell Kerr. Comparison of Bacterial Diversity within the Coral Reef Sponge, Axinella corrugata, the Encrusting Coral Erythropodium caribaeorum. Proceedings of the 11th International Coral Reef Symposium. In press, (2009).
Fabrice Berrue, Abdelnasser Ibrahim, Patricia Boland and Russell Kerr. A newly isolated marine Bacillus pumilus SP21: a source of novel lipoamides and other antimicrobial agents. Pure and Applied Chemistry 81, 1027-1031 (2009).
Jamie Frenz and Russell Kerr Sesquiterpene variability in the Gorgonian Genus Plexaurella. Comp. Biochem. and Physiol. C 150, 125-131 (2009).
Russell Kerr. Pseudopterosin production: the promise and challenges. Chapter in "Vision and Future of Investigations in Parasitology and Natural Products" Ministry of Education, Republic of Columbia, Bogota, (2009).
Fabrice Berrue and Russell G. Kerr. Dipterpenes from gorgonian corals. Nat. Prod. Rep., 26, 681-710 (2009).
Llanie K Ranzer, Thomas Brueck, Wolfram Brueck, Jose Lopez, Russell Kerr. A new prokaryotic farnesyldiphosphate synthase from the octocoral Eunicea fusca: differential display, inverse PCR, cloning and characterization. Marine Biotechnology, 11, 62 (2009).